White sponge nevus is a disease component of a group of inherited diseases that produce a white, bilateral, keratinized appearance typically appearing on the buccal mucosa. The term used for this type of genetically induced lesion within the family of white lesions is genokeratoses. White sponge nevus (WSN) is an autosomal-dominant disease that is caused by the mutation of certain keratin genes.
Keratin is the structural protein of epithelial cells. There is a defect in the normal keratinization (keratin 4 and keratin 13) that is expressed in the suprabasal keratinocytes of the buccal, nasal, esophageal mucosa, and anogenital tissue. The disorder is also most commonly known as familial, white-folded mucosal dysplasia, hereditary leukokeratosis, exfoliative leukoedema, and as Cannon's disease (described in 1909 by Hyde and given the name in 1935 by A. B. Cannon).
Oral Pathology
Selected repeats from Oral Pathology and Medicine... Go through all the questions….. Post your valuable Comments below …… All the best…. Thanks… :) :) :) :)
Keratin is the structural protein of epithelial cells. There is a defect in the normal keratinization (keratin 4 and keratin 13) that is expressed in the suprabasal keratinocytes of the buccal, nasal, esophageal mucosa, and anogenital tissue. The disorder is also most commonly known as familial, white-folded mucosal dysplasia, hereditary leukokeratosis, exfoliative leukoedema, and as Cannon's disease (described in 1909 by Hyde and given the name in 1935 by A. B. Cannon).
Oral Pathology
Selected repeats from Oral Pathology and Medicine... Go through all the questions….. Post your valuable Comments below …… All the best…. Thanks… :) :) :) :)
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